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| Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence |
| Ali Ben-Cheikh, Aymen Bali, Fatma Z Guerfali, Chiraz Atr, Hanène Attia, Dhafer Laouini |
| Korean J Parasitol. 2022;60(5):317-325. Published online 2022 October 21 DOI: https://doi.org/10.3347/kjp.2022.60.5.317 |
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Hypoxia-Inducible Factor-1 Alpha Stabilization in Human Macrophages during Leishmania major Infection Is Impaired by Parasite Virulence Schistosomiasis delays lesion resolution during Leishmania major infection by impairing parasite killing by macrophages Inhibitor of nuclear factor-kappaB alpha derepresses hypoxia-inducible factor-1 during moderate hypoxia by sequestering factor inhibiting hypoxia-inducible factor from hypoxia-inducible factor 1α Transcriptional Profiling of Macrophages Reveals Distinct Parasite Stage-driven Signatures During Early Infection by Leishmania Donovani Overexpression of a single Leishmania major gene enhances parasite infectivity in vivo and in vitro Stabilization of Hypoxia-Inducible Factor Promotes Antimicrobial Activity of Human Macrophages Against Mycobacterium tuberculosis Contribution of human neutrophils in the development of protective immune response during in vitro Leishmania major infection Hypoxia-Inducible Factor Signaling in Macrophages Promotes Lymphangiogenesis in Leishmania major Infection Hypoxia induces transforming growth factor beta 1 (TGFβ1) in human macrophages through a hypoxia inducible factor 1α (HIF-1α) – dependent mechanism Immunogenic proteins of Leishmania major during mouse infection |
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