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Korean J Parasitol > Volume 22(2):1984 > Article

Original Article
Korean J Parasitol. 1984 Dec;22(2):253-258. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1984.22.2.253
Copyright © 1984 by The Korean Society for Parasitology
Experimental meningoencephalitis by Naegleria fowleri in mice
Myoung-Hee Ahn and Kyung-Il Im
Department of Parasitology, College of Medicine, Hanyang University, Korea.

Experimentally, primary amoebic meningoencephalitis (PAM) is induced by Naegleria fowleri in mouse and development of PAM may be influenced by the strain, weight and sex of mouse, and inoculum size of N. fowleri trophozoite.

In this paper, the effect of these factors on PAM development of mouse was studied. N. fowleri trophozoites, strain 0359, were introduced into mouse intranasally under secobarbital anesthesia (0.05 mg/g).

1. PAM was developed more frequently in BALB/c mouse than ICR mouse.

2. The survival time of mouse with PAM was influenced by the weight, that is, it was shorter in 15 g mouse than in the heavier groups.

3. No difference was observed on PAM development according to sex.

4. In case of inoculated amoeba, PAM incidence of 0.5 × 104 was markedly decreased.


Fig. 1
Cumulative death rate of mice with PAM due to Nagleria fowleri infection according to sex.

Fig. 2
Cumulative death rate of mice with PAM due to Nagleria fowleri infection according to the weight.

Fig. 3
Numerous trophozoites of Nagleria fowleri are observed with a number of eosinophils, neutrophils or macrophages in mouse brain. (×1,000)


Table 1
Mortality of mice inoculated with Nagleria fowleri into nasal cavity

Table 2
Survival time of mice with PAM due to Nagleria fowleri infection

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