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Korean J Parasitol > Volume 19(2):1981 > Article

Original Article
Korean J Parasitol. 1981 Dec;19(2):95-100. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1981.19.2.95
Copyright © 1981 by The Korean Society for Parasitology
Anthelmintic effects of single doses of fenbendazole and oxantel-pyrantel pamoate to the intestinal nematodes
Han-Jong Rim,Joon-Sang Lee,Kyung-Hwan Joo and Yung-Shik Kim
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Korea.
Abstract

The present study was undertaken to evaluate the anthelmintic effects of fenbendazole against intestinal nematode; Ascaris lumbricoides, hookworm and Trichuris trichiura, and to compare the efficacy in fenbendazole, oxantel-pyrantel pamoate and placebo by means of double blind method.

Out of 114 subjects harbouring Ascaris lumbricoides, hookworm and Trichuris trichiura, 36 cases were treated with single dose of fenbendazole, 38 cases with oxantel-pyrantel pamoate, and the remaining 40 cases had received the placebo.

The results were as follows:

1. In the group treated with fenbendazole (30-50 mg/kg), the cure rates were 83.9 percent in 31 subjects with Ascaris lumbricoides and 83.3 percent in 18 subjects with hookworm, and only 28.6 percent in 28 subjects with T. trichiura respectively.

2. In the group treated with a single dose of oxantel-pyrantel pamoate (10 mg/mg), the cure rates were 96.7 percent in 30 subjects with A. lumbricoides, 95.2 percent in 21 subjects with hookworm, and 54.6 percent in 33 subjects with T. trichiura. Egg reduction rate was 85.7 percent in T. trichiura cases.

3. On the other hand, the egg negative conversion rates in placebo group were 9.7, 8.3 and 33.3 percent in Ascaris, Trichuris and hookworm infections respectively.

4. The above results showed that fenbendazole was highly effective against Ascaris and hookworm. However, incomparisom with oxantel-pyrantel pamoate, fenbendazole was less effective in regards of A. lumbricoides, hookworm and T. trichiura infections.

Tables


Table 1
Number of patients by age and sex in the treatment with fenbendazole, oxantel-pyrantel pamoate and placebo


Table 2
Incidence of multiple infection of intestinal nematodes in 114 subjects


Table 3
Effect of single dose of fenbendazole against intestinal nematodes


Table 4
Effect of single of oxantel-pyrantel against intestinal nematodes


Table 5
Effect of single dose of placebo against intestinal nematodes


Table 6
Side reactions of single dose fenbendazole, oxantel-pyrantel pamoate and placebo

References
1. Baeder C, et al. Experimentia 1974;30:753–754.
 
2. Brown HW. Anthelmintics, new and old. Clin Pharmacol Ther 1969;10(1):5–21.
 
3. Bruch K, Haas J. Effectiveness of single doses of Fenbendazole Hoe 88I against Ascaris, hookworm and Trichuris in man. Ann Trop Med Parasitol 1976;70(2):205–211.
 
4. Lim JK. Pyrantel Embonate And Bephenium Hydroxynaphthoate In The Treatment Of Hookworm Infection. Korean J Parasitol 1975;13(1):19–30.
 
5. Rim HJ, et al. Korea Univ Med J 1976;13:205–211.
6. Rim HJ, Ha JH, Lee JS, Hyun I, Uh KB. Pyrantel embonate in mass treatment of ascariasis and comparison with piperazine adipate and santonin-kainic acid complex. Korean J Parasitol 1974;12(2):141–146.
 
7. Rim HJ, Lee SH, Lee SI, Chang DS, Lim JK. Effect of Oxantel/pyrantel Pamoate Tablets Against Intestinal Nematodes In Korea. Korean J Parasitol 1978;16(1):14–20.
 
8. Rim HJ, et al. Asian J Med 1973;9:393–396.
9. Rim HJ, Won CY, Lee SI, Lim JK. Anthelmintic effect of oxantel pamoate and pyrantel pamoate suspension against intestinal nematode infestations. Korean J Parasitol 1975;13(2):97–101.
 
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