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Korean J Parasitol > Volume 15(2):1977 > Article

Original Article
Korean J Parasitol. 1977 Dec;15(2):121-126. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1977.15.2.121
Copyright © 1977 by The Korean Society for Parasitology
Anthelmintic effect of oxantel and oxantel/pyrantel tablets against intestinal nematode infections
Soon-Hyung Lee,Chul Yong Song and Jung Kyoo Lim
Department of Parasitology, College of Medicine, Chung-Ang University, Korea.
Department of Pharmacology, College of Medicine, Seoul National University, Korea.
Abstract

Present trial was carried out to evaluate the anthelmintic efficacy of oxantel/pyrantel tablets against intestinal nematode infections, and to determine the efficacy of oxantel tablels against Trichuris infection.

A total of 34 subjects with the mixed infections were treated with oxantel/pyrantel tablets (100 mg/tablet each) in a single dose of 15 mg/kg body weight, and another group of 22 Trichuris infected cases received oxantel pamoate tablets (125 mg/tablet) in a single dose of 15 mg/kg.

All stool examinations were done before the treatment and 3 weeks after the treatment. The cellophane thick smear (Kato's technique) and Stoll's dilution egg counting method were employed.

The results of the trial were summarized as follows:

1. The cure rates (egg negative conversion rates) and egg reduction rates for oxantel/pyrantel tablets were 85.3 percent and 97 percent in trichuriasis, 100 percent each in ascariasis and ancylostomiasis.

2. The oxantel tablet treated group demonstrated a cure rate of 90.9 percent and an egg reduction rate of 96.3 percent in the treatment of Trichuris.

3. There were no detectable objective and subjective side effects in this trial. Both oxantel/pyrantel and oxantel pamoate tablets were readily accepted and well tolerated.

Tables


Table 1
Prevalences of helminths in various groups surveyed by cellophane thick smear


Table 2
Status of multiple infection of intestinal nematodes among 34 subjects of present trial


Table 3
Anthelmintic efficacy of Oxantel/Pyrantel tablets against 34 mixed infection cases of present trial


Table 4
Distribution of T. trichiura infected cases by grades of EPG count


Table 5
Anthelmintic efficacy of Oxantel pamoate tablets against 22 Trichuris infected cases of present trial

References
1. Cho SY. Korean J Pharmacol 1976;12:69–73.
2. Lee SH, Seo BS, Cho SY, Kang SY. Clinical Trial Of Oxantel Pamoate(Cp-14, 445) On Trichocephalus Trichiurus Infection. Korean J Parasitol 1976;14(1):25–31.
 
3. Lim JK. Korean J Pharmacol 1974;10:97–101.
4. Park CW, et al. Seoul J Med 1973;14:228–232.
5. Rim HJ, et al. Korea Univ Med J 1976;13:205–211.
6. Rim HJ, Won CY, Lee SI, Lim JK. Anthelmintic effect of oxantel pamoate and pyrantel pamoate suspension against intestinal nematode infestations. Korean J Parasitol 1975;13(2):97–101.
 
7. Seo BS, Rim HJ, Loh IK, Lee SH, Cho SY, Park SC, Bae JW, Kim JH, Lee JS, Koo BY, Kim KS. [Study On The Status Of Helminthic Infections In Koreans]. Korean J Parasitol 1969;7(1):53–70.
 
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