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Korean J Parasitol > Volume 1(1):1963 > Article

Original Article
Korean J Parasitol. 1963 Jun;1(1):23-28. English.
Published online Mar 20, 1994.  http://dx.doi.org/10.3347/kjp.1963.1.1.23
Copyright © 1963 by The Korean Society for Parasitology
Phamacological studies of Lysimachia clethroides Duby
C. T. Soh,H. S. Kim and U. S. Kim
Department of Parasitology, Medical College, Yonsei University, Korea.
Abstract

The phamacological and anthelmintic action of Lysimachia clethroides were examined. Upon examining the action of water, ether, alcohol and acetone extrcts of the root on smooth muscle, it was found that the active principle was weakened by heating. Water and ether extracts inhibited the dehydrogenase of the worm. In 50% of 8 areas studied, Taenia were completely eliminated with 2.5~4.0 gm doses of the ether extracts, and no toxic effect was observed by the administration of the above-mentioned doses.

Figures


Fig. 1
Lysimachia clethorodes Duby.


Fig. 2
Tension movement of rabbit intestine treated with 0.01% water extract of Lysimachia clethorodes.


Fig. 3
Tension movement of rabbit intestine treated with 0.1% water extract of Lysimachia clethorodes.


Fig. 4
Tension movement of rabbit intestinal smooth muscle treated with 0.001% ethanol extract of Lysimachia clethorodes.


Fig. 5
Tension movement of rabbit intestinal smooth muscle treated with Tween 80 (5%) extract of Lysimachia clethorodes.


Fig. 6
Tension movement of rabbit intestinal smooth muscle treated with 0.001% ether extract of Lysimachia clethorodes.


Fig. 7
Tension movement of rabbit intestinal smooth muscle treated with 0.001% acetone extract of Lysimachia clethorodes.


Fig. 8
Tension movement of rabbit intestinal skeletal muscle treated with 0.1% water extract of Lysimachia clethorodes.


Fig. 9
Tension movement of rabbit intestinal skeletal muscle treated with 0.5% water extract of Lysimachia clethorodes.


Fig. 10
Tension movement of rabbit intestinal skeletal muscle treated with 0.5% ethanol or 0.5% acetone extract of Lysimachia clethorodes.


Fig. 11
Fatty liver occurred in mice treated for 3 days with 0.3 g, 0.3 g and 0.4 g ether extract of Lysimachia clethorodes.

Tables


Table 1
Survival time of tubifex teated with each extracts of Lysimachia clethorodes.


Table 2
Inhibitory effect of several extracts of Lysimachia clethorodes to Taenia saginata muscle dehydrogenase.


Table 3
Inhibitory effect of the ether and Tween 80 extracts of Lysimachia clethorodes to Hymenolepis diminuta muscle dehydrogenase.


Table 4
Effect of treatment with several extracts of Lysimachia clethorodes to Hymenolepis diminuta infected persons.


Table 5
Effect of treatment with ether extracts of Lysimachia clethorodes to Tenia saginata infected persons in 1961 spring.

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